Speaker
Description
Multiphoton microscopy uses nonlinear light-matter interactions to achieve non-destructive, label-free imaging, and is a rapidly emerging optical imaging technique for investigating biological samples. Nonlinear light is only produced by molecules with specific properties, such as fluorescent or non-centrosymmetric structures, allowing for chemically-selective images to be generated. Typically, the nonlinear light produced is very small and must be detected by a photodetector such as a photomultiplier tube or avalanche photodiode. Silicon photomultipliers (SiPM) are an attractive alternative for low-light detection due to their high gain, low cost, and small size. This talk explores an initial application of SiPMs in a multimodal, multiphoton microscope to image various biological and nonbiological samples, and identifies key benefits and challenges involved in their use.
